MI |
Mi15 |
Thymic stroma-derived T-cell growth factor |
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This lung cancer cell line has been established from the pleural effusion of a 69-year-old male with advanced large cell undifferentiated carcinoma of the lung complicated by leukocytosis (Harada et al, 2002). The conditioned medium of these cells contains high levels G-CSF. The cells form tumors in nude mice. The transplanted nude mice also showed leukocytosis with a high serum G-CSF level. The cells possess three copies of the G-CSF gene due to an additional chromosome 17 attached to a segment of chromosom e 10.
The inflammatory cytokines
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