MRJP-1 |
MRL/lpr |
fibronectin(680-704) |
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a stromal cell line established from murine thymic stroma. MRL104.8a cells express class 1 and class 2 H-2k antigens after exposure to IFN-gamma. MRL104.8a cells can maintain immature double-negative thymocytes. The cells support the growth of antigen-specific, IL2 dependent T-helper cell clones without requirement of antigen and exogenous IL2. The cells produce a T-cell growth factor (see: TSTGF) which can replace the stromal cells to promote growth of these T-helper cells.
MRL104.8a cells have been shown to produce constitutively high levels of LIF
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