mannan-binding protein C |
Mannose-6-phosphate receptor |
dedifferentiated Schwann cells |
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The old name of this Gram-negative opportunistic pathogen of cattle, sheep and other ruminants is Pasteurella haemolytica. This pathogen produces a variety of virulence factor thought to play an important role during the pathogenesis of bovine pneumonic pasteurellosis.
Mannheimia haemolytica leukotoxin abbr. Lkt) is a secreted cytolytic toxin encoded by an operon with a complex mosaic structure (Davies et al, 2002). The genes are homologous to the Escherichia coli hemolysin locus (hlyCABD).
The toxin specifically lyses bovine leukocytes. Low affinity binding that does not result in lysis has been demonstrated also for equine, porcine,
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