Mcpt5 |
Mcpt5-Cre R-DTA mice |
FF-type alpha motoneurons |
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(Mcpt5-Cre R-DTA mice) These mice have been generated by Dudeck et al (2011). They were generated by crossing mast cell protease-5-Cre transgenic mice with mice carrying a modified diphtheria toxin alpha chain so that the toxin is produced only in Cre-expressing cells. This construct permits conditional ablation of mast cells. Mast cell deficiency in these mice has been shown to impair emigration of skin dendritic cells to the lymph node and dramatically reduce contact hypersensitivity. Mast cell-specific inactivation of the IL10 gene does not reveal any role for mast cell-derived IL10
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