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Mcub

[modifier of cub] This mouse mutation has been shown to be a loss-of-function mutation in the gene encoding Amphiregulin (Siggs et al, 2014). Mcub suppresses the hair-loss phenotype of the curly bare (cub) mutation in the gene encoding iRhom2, a non-protease rhomboid-like protein that regulates trafficking and degradation of client proteins (Johnson et al, 2003). The cub mutation is a deletion of the N-terminal cytoplasmic domain of the Rhbdf2 gene (Siggs et al, 2014).

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