medium-field neurons |
MEDLEETLFEEFENYSYDLDYYSLESC |
BCL2-like molecule BLM-l |
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[Medium spiny neuron]
Medium spiny neurons, characterized by the presence of many spines on the dendrites, are the major output neurons of the striatum, a subcortical part of the forebrain that is the major input region of the basal ganglia system. Medium spiny neurons make up about 96 % of the striatum and receive input from cortex, thalamus, and substantia nigra. These neurons form complex neuronal loops within the basal ganglia that are important for the control of action, cognition, and emotion (Nakano et al, 2000).
Medium spiny neurons are characterized by their expression of DARPP-32 [dopamine- and cAMP-regulated phosphoprotein of 32 kDa]. DARPP-32 is localized primarily in those brain regions enriched in dopaminergic nerve terminals. It is present in neurons
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