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Mothers against decapentaplegic

The Drosophila Mad gene [mothers against dpp; gene: CG12399] has been identified by Sekelsky et al (1995). Mad is required for the Drosophila decapentaplegic (dpp), which encodes a growth factor that belongs to the TGF-beta superfamily and that plays a central role in multiple cell-cell signaling events throughout development. Homozygous Mad mutant animals exhibit defects in midgut morphogenesis, imaginal disc development and embryonic dorsal-ventral patterning that are very reminiscent of dpp mutant phenotypes.

This is the same as Mothers against decapentaplegic homolog 1. Abbr. MADH1 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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