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Mott cells are abnormal plasma cells characterized by the presence of Mott bodies or Russell bodies, which are rough endoplasmic reticulum-derived vesicles containing immunoglobulins of the IgM class (Tarlinton et al, 1992). These cells, which are defective in immunoglobulin secretion (Alanen et al, 1985, 1987) are seen frequently in lymphoid tissues of murine and human autoimmune diseases (Schweitzer et al, 1991; Shultz et al, 1987). They have been found to occur in multiple myeloma (Weinstein et al, 1987), and have been observed also in late stages of African trypanosomiasis (Rozman et al, 1986).
Jiang et al (1997) have reported that some subsets of B-cells (B-1 cells but not B-2 cells), can be induced in vitro to form Mott cells in the presence of LPS or IL5, but not other stimulants. Mott cell formation occurs at much higher frequencies in some strains of autoimmune mice than in non-autoimmune disease-prone mice or athymic nude mice. These Mott cells are characterized by the expression of B220, CD5, CD43, CD11b. Mott cell formation has been linked to a genetic locus, designated Mott-1, in close proximity to a locus associated with hypergammaglobulinemia.
For other entries pertaining to hematopoiesis see also the Hematology Dictionary section of this encyclopedia.
For other related/relevant entries see also: Cell types.
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ENTRY LAST MODIFIED: September 2006
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