Mott-1 |
Mouse-activating receptor 1 |
NGF receptor associated protein 1 |
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[Mott cell]
Mott cells (for overview see: Bain, 2009; McCormick et al, 2013; Cazzini et al, 2013; Bavle, 2013) are abnormal plasma cells characterized by the presence of Mott bodies or Russell bodies (for overview see: Bain, 2009; Mossuto et al, 2015), which are rough endoplasmic reticulum-derived vesicles containing immunoglobulins of the IgM class (Tarlinton et al, 1992). These cells, which are defective in immunoglobulin secretion (Alanen et al, 1985, 1987) are seen frequently in lymphoid tissues of murine and human autoimmune diseases (Schweitzer et al, 1991; Shultz et al, 1987). They have been found to occur in multiple myeloma (Weinstein et al, 1987), CD20(+) myeloma (Ramasamy et al, 2011), malignant B-cell lymphomas
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