Myxoma growth factor

abbr. MGF (a term with multiple meanings). This factor is encoded by a gene from the genome of myxoviruses. Sequence homologies reveal that this protein is a member of the EGF/TGF protein family (see also: EGF, TGF-alpha). For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.

Myxomavirus is a leporipoxvirus of rabbits that induces a lethal syndrome characterized by disseminated tumor-like lesions, generalized immunosuppression, and secondary Gram-negative bacterial infection. Viral deletion mutants lacking MGF sequences do not cause the characteristic disease symptoms of myxomatosis. Injected rabbits ... ... ... ...
 
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Entry last modified: June 1996