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[Neuron-derived neurotrophic factor] NDNF is a glycosylated, disulfide-bonded secretory protein that contains a fibronectin type III domain (Kuang et al, 2010). NDNF is evolutionarily conserved and has been found in invertebrate animals (Caenorhabditis elegans, Drosophila melanogaster). The designation NDNF was given to the gene product of human C4orf31 [chromosome 4 open reading frame 31], which is the human ortholog of the fly nord gene (gene CG13574
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