NIL16

[Neuronal IL16] Kurscher and Yuzaki (1999) have described the identification of NIL16 as a cytosolic protein detected only in neurons of the cerebellum and the hippocampus. Its N-terminal half constitutes a novel PDZ domain protein sequence (see also: Mühlhahn P et al, 1998) but the C-terminus is identical with mouse pro-IL16 derived from splenocytes. The N-terminal portion of NIL16 interacts selectively with a variety of neuronal ion channels (Fenster CP et al, 2007), which is similar to the function of many other PDZ domain proteins that serve as intracellular scaffolding proteins. The C-terminus of NIL16 can be processed by caspase-3, resulting in the release of secreted IL16.

Cerebellar granule neurons also express the ... ... ... ...
 
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Entry last modified: January 2018