NMA
[Non-metastatic gene A protein] The gene encoding this transmembrane protein has been identified by Degen et al (1996). Expression is high in poorly metastatic human melanoma cells and xenografts and completely absent in highly metastatic human melanoma cell lines. NMA is not expressed in normal skin tissue, but expression is high in melanocytes and in some melanoma metastases. Expression of NMA is high in human kidney medulla, placenta and spleen, low in kidney cortex, liver, prostate and gut, and absent in lung and muscle.
Sequence analysis shows that the encoded protein is the same as BAMBI [BMP and activin membrane-bound inhibitor].
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