NRA |
NRAGE |
IMP dehydrogenase 1 |
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[neurotrophin receptor alike death domain protein] NRADD is a protein with transmembrane and cytoplasmic regions highly homologous to death receptor regions, particularly the neurotrophin receptor p75NTR. The protein contains a death domain (Wang et al, 2003).
Expression of NRADD induces cell death by apoptosis in a number of cell lines. The process involves activation of caspase-8 and does not require mitochondrial components (see also: intrinsic apoptosis). Deletion of the N-terminal domain of the protein yields a dominant-negative form of NRADD that protects neurons and Schwann cells
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