NRGN(55-78) |
Nrh |
angiotensinase A |
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[Negative Regulator of Haematopoiesis] This acidic, glycosylated heparin binding protein (approximately 20 kDa) is found in the conditioned medium of the human macrophage line 2MAC. It acts as a reversible suppressor of early hematopoietic progenitor cells of the BFU-E type (see also: hematopoietic stem cells, Hematopoiesis), markedly decreasing the cycling of early progenitor cells (see also: cell cycle). The factor suppresses the cycling of [high proliferative potential colony-forming cells, HPP-CFC, in CD34(+) preparations obtained from mobilized peripheral blood
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