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Neurite inducing factor

abbr. NIF (a term with multiple meanings). This biochemically uncharacterized factor of approximately 20 kDa is isolated from murine submaxillary glands. It induces the outgrowth of neurites in the pheochromocytoma cell line PC12. The factor is not identical with NGF since its activity is not blocked by NGF-specific antibodies (Wagner et al, 1986). The factor does not stimulate the proliferation of neuroblastoma cells (Lüdecke and Unsicker, 1990).

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