Neuroparsin B |
neuropathy, axonal, motor-sensory with deafness and mental retardation |
Non-adherent three-dimensional cell culture |
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Neuroparsin has been identified originally as a hormone in the African migratory locust, Locusta migratoria, that inhibits vitellogenesis (Girardie et al, 1989). It is produced by the pars intercerebralis, the major center of neuroendocrine cells in the insect brain. Apart from its involvement in reproduction, the hormone also affects development and seems to have effects opposite of those of Juvenile hormone (Girardie et al, 1989). The role for neuroparsin in locust reproduction and development appears to be independent of juvenile hormone, but treatment of locusts with juvenile hormone or ecdysone increases transcription of the neuroparsin gene (Claeys et al, 2006).
Other effects of neuroparsin
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