New Zealand black mice serum factor |
Nexin-1(106-119) |
leucine-rich and death domain containing protein |
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[protease nexin-1]; abbr. PN-1. The protein is being referred to also as SERPINE2 [serpin peptidase inhibitor clade E member 2]. Nexin-1 is a Heparin binding glycoprotein (see also: HBGF) of 44 kDa released by human foreskin fibroblasts and cultured glial cells. The protein is present also on the surface of fibroblasts, bound to the extracellular matrix. PN-1 represents about 1 % of their secreted proteins.
Nexin-1 is a broad specificity inhibitor of trypsin-like serine proteases, preferentially binding to thrombin, urokinase, trypsin, and plasmin. Heparin accelerates the rate of
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