Notch-2 |
Notch-4 |
actin-gamma-2 |
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[Neurogenic locus notch homolog protein 3] one of the genes related to Notch. Notch-3 (human chromosome 19p13.2-p13.1) lacks some of the domains found in Notch-1 and Notch-2 and encodes a considerably shorter intracellular domain (Lardelli et al, 1996). Ligands of Notch-3 are delta-1, jagged-1, jagged-2.
Several Notch receptors are cleaved intracellularly upon ligand activation. The intracellular Notch domain then translocates to the nucleus and modulates gene expression. The cleaved intracellular domain of Notch-3 may function as a repressor of gene activation mediated by the cleaved
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