PAFP-S

[Phytolacca antifungal protein] PAFP-S is a highly basic antifungal peptide (AGCIKNGGRCNASAGPPYCCSSYCFQIAGQSYGVCKNR) isolated from seeds of Phytolacca americana (American pokeweed; Phytolacca decandra) (Shao et al, 1999). PAFP-S shares significant sequence similarity with antimicrobial peptides from Mirabilis jalapa (Mj-AMP). PAFP-S contains a knottin motif (Gao et al, 2001), and a hydrophobic surface essential for its interaction with fungal membrane lipids and the antifungal activity (Peng et al, 2005).

PAFP-S exhibits a broad spectrum of antifungal activity. It is inactive on Escherichia coli. The peptide has been described independently as Pa-AMP-1 [Phytolacca americana antimicrobial peptide-1 ... ... ... ...
 
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Entry last modified: July 2013