PAN1 |
PAN3 |
CSRARKQAASIKVAVSADR |
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[PAAD and NACHT-containing protein 2] This protein of 110 kDa has been identified by Fiorentino et al (2002) by bioinformatics strategies employed in search of proteins containing a PAAD domain. The protein contains a PAAD domain, a putative nucleotide binding domain (NACHT), several leucine-rich repeat domains, and resembles Cryopyrin, a protein implicated in hereditary hyperinflammation syndromes. The protein has been termed PYPAF4 [Pyrin-containing APAF-1-like protein 4].
PAN2 has been shown to modulate the activity of transcription factor NF-kappa-B
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