PARPBP |
PARS |
Glycoprotein hormone alpha 2 ortholog |
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This enzyme cleaves and inactivates PARP1 [poly(ADP-ribose) polymerase 1] (Nicholson et al, 1995). Inactivation of this polymerase is one of the early steps of cell death by apoptosis. The cleavage protease has been termed apopain and is identical with caspase-3.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.
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