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PDZ domain

[PDZ domains]

PDZ domains protein-protein interaction domains with a length of approximately 90 amino acids. The acronym was coined from the first three proteins in which they were identified: the postsynaptic protein PSD-95/SAP90, the Drosophila melanogaster septate junction protein Discs-large, and the tight junction protein ZO-1. These domains occur in multiple proteins in many different organisms and are among the most common protein domains known (Bezprozvanny and Maximov, 2001; Kennedy, 1995; Vaccaro and Dente, 2002).

PDZ domains bind the carboxyl termini of proteins. Frequently, these domains occur in multiple copies and/or are closely grouped in tandem arrays comprising two or three such domains. Proteins that contain PDZ interaction domains ... ... ... ... ... Subscribe to continue reading! ... ...

 

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