PK-R2 |
pks island |
G-protein-coupled receptor-5 |
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This targeting peptide (Pro-Lys-Arg-Gly-Phe-Gln-Asp) has been isolated by combinatorial peptide library screening in vivo on a human prostate cancer xenograft that is androgen-independent and induces a robust osteoblastic reaction in bone-like matrix and soft tissue. The peptide is enriched in the tumors, targets the cell surface of androgen-independent prostate cancer cells in vitro, and in vivo homes to prostate cancer that do not express androgen receptor. Alpha-2-Macroglobulin has been identified as a receptor for this peptide (Mandelin et al, 2015).
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