PSGL |
PSH |
glioma homing peptide |
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[P-selectin glycoprotein ligand-1] In the nomenclature of CD antigens this protein has been given the designation CD162. Veldman et al (1995) have cloned the PSGL-1 gene from a human placenta genomic DNA library. The mouse geen has been cloned by Yang et al (1996).
Spertini et al (1996) have shown that PSGL-1 binds to CD62L (L-selectin). Modification of PSGL-1 by glycosyltransferases has been shown to permit T-cell migration (Th1 cells buit not Th2 cells) to inflammatory sites via binding to P-selectin or E-selectin
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