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Palifermin

Tradename for a recombinant N-terminally truncated form of KGF [keratinocyte growth factor]. The recombinant factor has a biologic activity similar to that of the native protein, but shows increased stability (Rubin et al, 1989). The recombinant protein has been shown to protect several types of epithelial tissues in animal models of chemotherapy, radiotherapy, and hematopoietic stem-cell transplantation (Farrell et al, 1998, 1999) and appears to be tolerated without major adverse effects in phase I clinical studies (Meropol et al, 2003; Spielberger et al, 2004).

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