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Pentraxin-3

This protein is known also as Pentaxin-3. The gene symbol is PTX3. The designation TNFAIP5 [tumor necrosis factor-alpha-induced protein 5] is an old gene symbol that has been withdrawn. In databanks the Pentraxin-3 gene appears also as pentraxin-related gene rapidly induced by IL1-beta.

The cDNA encoding this protein of 381 amino acids has been cloned by Breviario et al (1992) and identified as a gene the expression of which is induced in human umbilical vein endothelial cells by IL1-beta. The gene has been identified independently as TSG-14 by Lee et al (1990, 1993).

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