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PfTyrRS

[Plasmodium falciparum Tyrosyl-tRNA synthetase] Bhatt et al (2011) have reported that PfTyrRS induces pro-inflammatory responses from host immune cells. PfTyrRS is released into the extracellular medium following lysis of infected red blood cells. Using its ELR peptide motif, PfTyrRS specifically binds to and internalizes into host macrophages, leading to enhanced secretion of the pro-inflammatory cytokines TNF-alpha and IL6. PfTyrRS also augments expression of adherence-linked host endothelial receptors ICAM-1 and VCAM-1. See also: Tyrosyl-tRNA synthetase. ... ... ... ... ... Subscribe to continue reading! ... ...

 

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