pH2-stable interferon |
PH-30 |
immediate early genes |
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This peptide, AQFHRHKQLIRFLKRA, has been identified by Klementiev et al (2013). The peptide is modeled after the IL4 binding site for IL4R-alpha and encompasses alpha-helix C of IL4 involved in the interaction with IL4R-alpha. It binds to the ectodomain of IL4R-alpha with an affinity comparable to that of the cytokine and mimics the binding properties of IL4. The peptide mimics the anti-inflammatory effects of IL4 by inhibiting TNF-alpha production by macrophages in vitro.
The peptide induces the phosphorylation of STAT6
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