pim-1 |
Pim-3 |
CDw327 |
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[Proviral Integration of Moloney virus 2] The Pim-2 oncogene has been identified originally as a proviral insertion site in the lymphomas that arise following infection with the Murine Moloney Leukemia virus (Breuer et al, 1989; van der Lugt et al, 1995; Allen et al, 1997). The human gene encoding the Pim-2 oncogene has been cloned by Baytel et al (1998). Human and mouse proteins share 90 % identity.
The oncogene encodes a serine/threonine kinase involved in oncogenesis and malignant cell transformation (Allen et al, 1997). Dysregulated Pim-2 expression is found in a variety of cancers such as prostate cancer (Dhanasekaran et al, 2001; Dai et al, 2005),
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