R-spondin |
R-spondin-2 |
CG2171 |
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[roof plate-specific spondin] This is the same as R-spondin. Abbr. Rspo (Rspo-1). R-spondin-1 has been identified by Kamata et al (2004) as a gene expressed in the dorsal neural tube. The protein appears to be a nuclear protein but can be secreted also. R-spondin-1 has been identified independently as Cristin-3.
Kim et al (2005) have reported that R-spondin-1 is expressed in enteroendocrine cells and in epithelial cells in various tissues. Zhao et al (2007) have localized R-spondin-1 protein to villus epithelium and crypt Paneth cells in mouse small intestine.
Injection of the protein into mice induces rapid onset of crypt
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