Horst Ibelgaufts' COPE: Cytokines & Cells Online Pathfinder Encyclopaedia COPE needs your support to remain a free service!

REG

[regenerating gene] This gene is called also REG1 [regenerating islet derived-1] or Islet of Langerhans regenerating protein 1. The gene product of the REG gene has been identified independently as lithostathine (pancreatic stone protein). REG is a member of a gene family comprising REG, REG1, REG2, and REG3.

REG is expressed in regenerating liver or regenerating islets in the pancreas, but not in the equivalent normal tissues (Terazono et al, 1988). The protein may be involved in the regeneration and/or growth of pancreatic beta-cells (Baeza et al, 1997). Ashcroft et al (2004) and Fukui et al (1998) have reported that the expression of REG in stomach ECL cells is induced by gastrin. The protein thus may be involved in the growth of mucosal cells induced by gastrin. Highham et al (1999) have reported that mutations of the gene are associated with the development of tumors derived from ECL cells in patients with high blood levels of gastrin. Miyaoka et al (2004) have reported that transgenic overexpression of REG caused gastric cell proliferation and differentiation along parietal cell and chief cell lineages. REG protein stimulates the proliferation of vartious types of gastric cancer cells. In addition, patients with gastric cancers expressing REG appear to have a poorer outcome (Kinoshita et al, 2004)

LAST MODIFIED: March 2005

See REFERENCES for entry REG

#

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

S

T

U

V

W

X

Y

Z

Space for your TEXTLINK ADVERTISEMENTS. Please Inquire

---

---

supports the COPE bioinformatics project with an unrestricted educational grant
Inquiries from other sides welcome

---

Created, developed, and maintained by Prof Dr H Ibelgaufts               About the author of COPE   |    Contact COPE   |    postcard and stampware

---

Access to COPE is free only for academic institutions and non-profit organizations. OTHER USERS: must contact COPE and pay a site licence fee. Non-payment of the site licence fee is a serious breach of COPE's binding Usage Agreement. If you do not wish to be bound by this agreement, do not use COPE

COPE is not in the public domain! The commercial use of COPE contents is not allowed. Download of complete offline-readable copies and the use of automatic extraction methods are prohibited! Usage Agreement, Disclaimer, Copyright Notice   |  All rights reserved by H Ibelgaufts   |  Privacy Statement U L T R A   P O S S E   N E M O   O B L I G A T U R

cope.cgi version 24.7.04, revision Jan 15, 2010. (c) JI. Powered by Perl 5.008008 [b=6]