SCCKN |
SCCTF |
Epidermal keratinocyte-derived basophil promoting activity |
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The expression of this gene is inducible by TNF-alpha (Kumar et al, 2000). The protein contains a DED domain and resembles FLIP. SCC-S2 mRNA is expressed in most normal tissues and malignant cells. SCC-S2 acts as a negative mediator of cell death by apoptosis in certain cell types. Ectopic expression of SCC-S2 in cancer cells causes enhanced growth rat and cell viability, an increase in cell migration, and enhanced tumor growth in nude mice.
SCC-S2 has been identified independently as NDED and GG2-1. The approved gene symbol for these genes is TNFAIP8 [
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