Sem-5 |
Sem A |
ICP27 |
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[semenogelin-1(86-107)] This peptide has been identified as a short, cationic, amyloidogenic peptide (DLNALHKTTKSQRHLGGSQQLL) that is generated from semenogelin-1 early in the process of semen liquefaction and is lost during prolonged liquefaction due to the activity of serine proteases (Robert et al, 1997). SEM1(86-107) amyloids are naturally present in semen. The peptide binds HIV1 virions and can enhance HIV infection of permissive cells. Levels of this peptide correlate with virus-enhancing activity over the course of liquefaction (Roan et al, 2011).
For other proteins (or fragments thereof) with at least one additional activity that differs from the established 'classical' activity of the parent protein see also:
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