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SEM1(86-107)

[semenogelin-1(86-107)] This peptide has been identified as a short, cationic, amyloidogenic peptide (DLNALHKTTKSQRHLGGSQQLL) that is generated from semenogelin-1 early in the process of semen liquefaction and is lost during prolonged liquefaction due to the activity of serine proteases (Robert et al, 1997). SEM1(86-107) amyloids are naturally present in semen. The peptide binds HIV1 virions and can enhance HIV infection of permissive cells. Levels of this peptide correlate with virus-enhancing activity over the course of liquefaction (Roan et al, 2011).

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