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SIGLEC-6

[sialic acid binding immunoglobulin-like lectin 6] This protein is a member of a family of type 1 transmembrane proteins. They are cell surface lectins that have the ability to bind to sialic acids and mediate interactions between proteins and carbohydrates (see also: SIGLECs). Several studies describing the sialoside specificities of individual SIGLECs have been reported (Blixt et al, 2003; Rapoport et al, 2006).

The cDNA encoding this protein of 442 amino acids has been identified by Takei et al (1997), who called it CD33 antigen-like (CD33L) due to high sequence similarity with the myeloid antigen CD33. They also identified an alternatively spliced transcript lacking the transmembrane and cytoplasmic regions of the protein, ... ... ... ... ... Subscribe to continue reading! ... ...

 

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