SIRS |
SIRT1 75 kDa fragment |
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[sirtuin-1; silent information regulator T1] SIRT1 (Frye, 1999) is one of several proteins known collectively as sirtuins. The protein is being referred to also as SIR2L1 [Sir2-like 1; silent information regulator 2-like 1] or SIR2-alpha. Sirtuin-1 has closest homology to yeast Sir2 [silent information regulator 2] (Shore et al, 1984), a protein that regulates epigenetic gene silencing.
SIRT1 is an NAD(+)-dependent histone deacetylase (Imai et al, 2000; Vaquero et al, 2004) that acts as a stress-response and chromatin-silencing factor (Abdelmohsen et al, 2007).
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