SVAGRAQGM |
sVEGFR1 |
LGR4 |
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[small vasohibin-binding protein] This protein of 66 amino acids is secreted constitutively by endothelial cells and binds to vasohibin (Suzuki et al, 2010). In databanks the protein has been filed also under the name CCDC23 [Coiled-coil domain-containing protein 23].
The protein is thought to be involved in the secretion of vasohibin as a secretory chaperone and also inhibits ubiquitylation of vasohibin. Knock-down of SVBP expression markedly reduces secretion of vasohibin. SVBP thus contributes to the anti-angiogenic activity of vasohibin.
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