SCASRCKGHCRARRCGYYVSVLYRGRCYCKCLRC |
Scatter factor |
KDCERRFSRSDQLKRHQRRHTGVKPFQ |
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Graphical representation of equations describing protein-ligand binding and analyzing equilibrium binding data. Raw data (dpm) are obtained from ligand binding experiments such as radioreceptor assays or radioimmunoassays. Characteristic to both methods is the saturable, specific, competitive and reversible interaction between ligands and their receptors or suitable antibodies. Such assays are widely used to determine cytokine concentrations (see also: cytokine assays) and to obtain information about receptor densities and receptor types.
Scatchard analyses have provided valuable information about cytokine receptor affinities and often have revealed the existence of low and high affinity binding sites. If concentrations of a radiolabeled bound ligand for a cytokine
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