ShIF
[short immune suppressor factor] This 27 kDa factor is a soluble variant of ISF (immune suppressor factor) (Lee C et al, 1990), a membrane protein harboring six transmembrane domains and possessing immunosuppressive functions. ShIF shares high sequence homology to the yeast vacuolar H(+)-ATPase subunit, Vph1p, and the 116 kDa proton pump of the rat and bovine synaptic vesicle, Vpp1 (Tulin et al, 2001). In databanks the factor is found as Immune suppressor factor J6B7, which is a proteolytic cleavage product of the ATPase ATP6V0A2 (approved gene symbol) (see there for more information on immunomodulatory activity)
ShiF is produced by
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