SLIT3 |
slit guidance ligand 1 |
epiviosamines |
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[slit homolog-3] This human gene (approved gene symbol: SLIT3 [slit guidance ligand 3]) is related to Drosophila melanogaster slit (Itoh et al, 1998). The gene is called also MEGF5 [multiple epidermal growth factor-like domains 5] because it contains several copies of an EGF-like repeat (Nakayama et al, 1998). The gene is expressed predominantly in the thyroid.
Although Slit-3 is localized to the cell surface, Slit-3 also appears to contain an aminoterminal mitochondrial localization signal. Thus, Slit-3 may have unique functions not shared by other Slit proteins (Little et al, 2001).
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