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TDRD12

(approved gene symbol) [tudor domain containing 12] The gene contains a Tudor domain and has been described as ECAT8 [embryonic stem cell-associated transcript 8; ES cell-associated transcript 8], one of the genes enriched in mouse embryonic stem cells by in silico differential display screening (Mitsui et al, 2003).

The protein is probably an RNA helicase and has been shown to be involved in piRNA biogenesis, playing a role in repressing transposable element mobilisation, which is required during spermatogenesis for maintaining germline integrity (Pandey et al, 2013; Yang Z et al, 2016). The function in piRNA biogenesis is conserved in Drosophila melanogaster (Handler et al, 2011). In ... ... ... ... ... Subscribe to continue reading! ... ...

 

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