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TFAP2C

(approved gene symbol) [transcription factor AP-2-gamma]. The factor is being referred to also as TFAP2G [transcription factor AP-2-gamma] and AP-2 gamma [activating enhancer binding protein 2 gamma].

The gene for this transcription factor, which binds the GCCNNNGGC motif, has been cloned by Williamson et al (1996). McPherson et al (1997) have purified the TFAP2C protein from an estrogen receptor-positive breast cancer cell line and referred to it as ERF1 [estrogen receptor factor 1].

Werling and Schorle (2002) have generated knock-out mice lacking expression of TFAP2C. Heterozygous ... ... ... ... ... Subscribe to continue reading! ... ...

 

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