TFPI |
TFPI-2 |
collagen-4-alpha-4(1524-1543) |
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[tissue factor pathway inhibitor-1; also simply TFPI] This Kunitz-type serine protease inhibitor inhibits the activation of the extrinsic coagulation cascade through its ability to inhibit factor Xa and complexes between factor VII and tissue factor (Broze and Miletich, 1987). TFPI neutralizes the catalytic activity of factor Xa and is engaged in feedback inhibition of the TF factor VIIa (FVIIa) complex in the presence of factor Xa (Broze, 1992; Broze et al, 1988).
The factor is known also as EPI (extrinsic pathway inhibitor) (Rao and Rapaport, 1987) and LACI (
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