TFRC |
TfsvVEGF |
HEP |
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[follicular regulatory T-cells; T follicular regulatory cells] These cells constitute a population of FOXP3(+) BLIMP1(+) CD4(+) T-cells that make up 10-25 % of the CXCR5(high) PDCD1(high) CD4(+) T-cells found in germinal center after immunization. The cells share phenotypic characteristics with TFH cells and conventional FOXP3(+) regulatory T-cells but are distinct from either. Similar to TFH cells the development of TFR cells depends on BCL6, SAP, CD28 and B-cells
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