TGF-beta-1 induced anti-apoptotic factor-1 |
TGF-beta-1-LAP |
TSG-8-1 |
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abbr. TIE. a regulatory gene sequence found in the promoter regions of several genes the expression of which is controlled negatively by TGF-beta-1 (see: TGF-beta) through binding of a protein complex also containing fos. Examples are the human platelet-activating factor receptor transcript 2 (tissue-type), Stromelysin, HGF. It has been suggested that in some tumors low levels of TIE-binding protein may result in an escape from growth inhibition by TGF-beta. See also: Response elements.
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