TGLYICMNKKGKLIAK |
TGNYKALHPHNG |
chromogranin A (19-146) |
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(also: Pep TGN) This targeting peptide with the sequence TGNYKALHPHNG has been identified by phage display library screening in a search for peptides that target the blood-brain barrier and can enhance brain-specific drug delivery. Intravenous injection of nanoparticles coated with TGN peptide show enhanced brain accumulation efficiency together with lower accumulation in liver and spleen in nude mice. (Li et al, 2011).
Gao et al (2012) and Ma et al (2014) have used nanoparticles functionalized with TGN peptide and AS1411 a quadruplex-forming oligonucleotide aptamer anticancer agent that targets nucleolin. In vitro cell uptake and three-dimensional tumor spheroid
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