TIP-alpha

[TNF-alpha-inducing protein] This protein is encoded by the HP0596 gene of Helicobacter pylori and is unique to Helicobacter pylori. The protein is found as a homodimer (38 kDa) in extracts and culture medium of various Helicobacter pylori strains. It significantly induces TNF-alpha gene expression and NF-kappa-B activation and can also induce cell transformation in vitro. The protein can induce expression of pro-inflammatory cytokines (TNF-alpha, IL1) in the stomach (Suganuma et al, 2005). TIP-alpha can stimulate macrophages to produce IL1-alpha and TNF-alpha (Godlewska et al, 2008).

The protein enters gastric cancer cells ... ... ... ...
 
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Entry last modified: December 2017