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[Thymic immunosuppressive pentapeptide] This pentapeptide, AEWCP, has been obtained from calf thymic immunosuppressive extract. In an ovalbumin-induced mouse allergic asthma model, TIPP significantly inhibits the increase in Th2 cytokines and OVA-specific IgE production, mRNA levels of IL4, TNF-alpha and eotaxin-1 and the expression of MCP-1, VCAM-1 and COX-2 in lung tissues, and effectively counteracts balance changes of cells in bronchoalveolar lavage fluid. The administration of TIPP suppresses allergic and inflammatory responses in allergic mice via blocking MAP kinases / NF-kappa-B
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