TLR14 |
TLR16 |
DIM-2 |
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[Toll-like receptor-15] TLR15 has been identified by Higgs et al (2006). It is distinct from any known vertebrate Toll-like receptors and appears to be avian specific. Woods et al (2009) have reported expression of TLR15 within granulosa cells of the laying hen. This receptor, like other toll-like receptors, plays a role in innate immunity by acting as a pattern recognition receptor.
de Zoete et al (2011) have reported that TLR15 is a sensor for secreted virulence-associated fungal and bacterial proteases. Activation of TLR15 involves proteolytic cleavage of the receptor ectodomain and stimulation of NF-kappa-B dependent gene transcription.
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