TLT-4 |
TLTYTWS |
immature B-cells |
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[trypanosome lymphocyte-triggering factor] This factor (453 amino acids) was observed originally by Olsson et al (1991). The protein is called also Trypanin. It is produced by various species of trypanosomes, including Trypanosoma brucei brucei, T. evansi, T.b. gambiense and T.b. rhodesiense (Bakhiet et al, 1996) (see also: trypanokine). TLTF is a component of the detergent-resistant and calcium ion-resistant fraction of the parasite cytoskeleton (Hill et al, 2000).
TLTF-related genes are present in several highly divergent eukaryotic organisms (Hill et al, 2000). The mammalian TLTF-like gene has been identified as gas-11.
IFN-gamma induces the production of TLTF in CD8(+) T-cells
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